The basic concept of the tool is to point out a the main directory containing the AMD modules, and a test directory containing test or spec written in AMD styling. And then run testister from command line.
Testister can also be run in server mode. This start the http server and expose the testsuits url. (http://localhost:/test/). This make the test able to be run in a browser of your choce (FF,safari,ie...) and able to test browser specific funktionallity.